It’s perfectly normal for our skin to get wrinkles and fine lines as we age—but if you’re looking to achieve a smoother-looking complexion, the best wrinkle fillers can help. Often marketed as injectable filler alternatives or “Botox in a bottle” skincare products, these topical products are “designed to minimize the appearance of lines,” explains Joshua Zeichner, M.D., a board-certified dermatologist and director of cosmetic and clinical research in dermatology at the Mount Sinai Medical Center in NYC.
But how exactly do wrinkle fillers work? They “pull in hydration to the skin to give a plumping effect,” explains Dr. Zeichner. It’s all thanks to their ingredient list, according to Deanne Mraz, M.D., F.A.A.D., President and Co-Founder of Modern Dermatology of Connecticut. “Depending on the product, most will include a variety of active ingredients such as antioxidants that protect and repair, peptides to supportive collagen synthesis, and AHAs/retinols to increase skin cell turnover rate,” she says.
Meet the experts: Joshua Zeichner, M.D., a board-certified dermatologist and director of cosmetic and clinical research in dermatology at the Mount Sinai Medical Center in NYC; Deanne Mraz, M.D., F.A.A.D., board-certified dermatologist, President and Co-Founder of Modern Dermatology of Connecticut; and Marisa Garshick, M.D., a board-certified dermatologist at MDCS Dermatology in NYC.
In addition to retinols and peptides, many topical wrinkle fillers are also formulated with hyaluronic acid, which also happens to be the ingredient found in in-office, injectable dermal fillers, notes Marisa Garshick, M.D., a board-certified dermatologist at MDCS Dermatology in NYC. “Wrinkles may be addressed in different ways, with dermal filler being a good option for deeper folds and wrinkles that often result from volume loss—but not all wrinkles can be treated with in-office filler,” she says. For individuals who want to avoid invasive procedures or in-office injectables, topical wrinkle filler products can be a suitable (albeit more temporary) alternative for smoother skin.
So, which wrinkle fillers are best? Ahead, we tapped dermatologists to share their top-recommended products that help plump and smooth out forehead wrinkles, smile lines, crow’s feet (wrinkles around the eyes), and more. From top-rated anti-wrinkle serums to hydrating wrinkle creams, shop the best wrinkle fillers below for a more hydrated, youthful-looking complexion.
” data-next-head/>“,”jobTitle”:”Associate Style & Commerce Editor”,”image”:”https://hips.hearstapps.com/rover/profile_photos/75d89ec3-0683-4831-8915-edd0a0ac1db4_1705010672.jpg”},{“name”:”Charlotte Lewis Finigan”,”url”:”https://www.prevention.com/author/407279/charlotte-lewis/”,”@type”:”Person”,”description”:”
Charlotte Lewis Finigan is the Senior Commerce Editor at Prevention. After a decade of working in Hollywood writers’ rooms and contributing pop culture writing to ETOnline, Bustle, TVGuide, and CBS, she underwent bariatric surgery and changed her focus to health and wellness. Previously, Charlotte was the Sexual Health & Wellness Writer for Refinery 29. There, she wrote and edited shopping content about new wellness trends, beauty launches, and sex-positive products. She currently lives in Brooklyn with her girlfriend—and the love of her life, her senior dog, Rory. All three can typically be found perusing the Fort Green farmer’s market for fresh produce or curling up on the couch to watch Survivor.
“,”jobTitle”:”Senior Commerce Editor”,”image”:”https://hips.hearstapps.com/rover/profile_photos/0f68a31c-b61c-4c5d-a41a-3d384a50184c_1720371390.file”}],”about”:{“@type”:”ItemList”,”numberOfItems”:20,”itemListElement”:[{“@type”:”ListItem”,”position”:1,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Derm Correxion Fill + Treat Serum”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-1″,”description”:”RoC’s wrinkle-filling serum comes recommended by multiple of our experts for its advanced formulation. “Containing both retinol and hyaluronic acid, this helps to instantly improve the appearance of fine lines and wrinkles, while also helping to boost collagen production, and continue to improve the appearance of fine lines and wrinkles over time,” Dr. Garshick explains. “It combines hyaluronic acid for immediate plumping along with a stabilized form of retinol to stimulate collagen and strengthen the skin with continued use,” Dr. Zeichner also says.What a reviewer says: “I have been trying quite a few different creams to tackle wrinkles…I can’t believe it but this stuff works,” one Amazon reviewer shared. “I noticed a difference the next day. Have been using it twice a day now for a week and it is working. The wrinkles on my forehead are so minimal now it’s great—even the deep ones between my eyebrows look better, and laugh lines are better. So happy finally found something that works. “,”image”:”https://vader-prod.s3.amazonaws.com/1771356856-71zcdfvozbl-sl1500-6994c29abe21a.jpg”,”brand”:{“@type”:”Brand”,”name”:”RoC”},”review”:{“@type”:”Review”,”name”:”Derm Correxion Fill + Treat Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1771356856-71zcdfvozbl-sl1500-6994c29abe21a.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”RoC’s wrinkle-filling serum comes recommended by multiple of our experts for its advanced formulation. “Containing both retinol and hyaluronic acid, this helps to instantly improve the appearance of fine lines and wrinkles, while also helping to boost collagen production, and continue to improve the appearance of fine lines and wrinkles over time,” Dr. Garshick explains. “It combines hyaluronic acid for immediate plumping along with a stabilized form of retinol to stimulate collagen and strengthen the skin with continued use,” Dr. Zeichner also says.What a reviewer says: “I have been trying quite a few different creams to tackle wrinkles…I can’t believe it but this stuff works,” one Amazon reviewer shared. “I noticed a difference the next day. Have been using it twice a day now for a week and it is working. The wrinkles on my forehead are so minimal now it’s great—even the deep ones between my eyebrows look better, and laugh lines are better. So happy finally found something that works. “,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Fills in lines and smooths wrinkles in target areas”},{“@type”:”ListItem”,”position”:”2″,”name”:”Contains retinol”},{“@type”:”ListItem”,”position”:”3″,”name”:”Hydrates and plumps skin with hyaluronic acid”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Comes in a small tube”}]}}}},{“@type”:”ListItem”,”position”:2,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Immersive Hydration Moisture Boost Serum”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-2″,”description”:”According to the pros, hyaluronic acid is a key ingredient to look for in wrinkle fillers (there’s a reason it’s the main ingredient in in-office dermal fillers!). “This serum delivers two forms of hyaluronic acid, both low and high molecular weight, to hydrate, smooth, and fill the skin both deep in the skin and at the surface,” Dr. Zeichner explains. In addition to containing a highly concentrated form of hyaluronic acid, this lightweight is also non-comedogenic (meaning it won’t clog pores) and is suitable for all skin types, including sensitive skin.What a reviewer says: “I was excited to try a serum as someone who is always looking for the fountain of youth for anti-aging. Hyaluronic acid is one of the most important ingredients in my opinion for dulling fine lines and wrinkles,” said one shopper. “This serum has a light, clean scent that I enjoyed. The gel is thick enough that it applies evenly and absorbs quickly. I found my skin to be surprisingly soft after using. In fact, I didn’t necessarily even need a moisturizer and will often use it on its own after cleansing. This may be one of the most impactful serums I’ve used!””,”image”:”https://vader-prod.s3.amazonaws.com/1708532975-71-lEoEV8ZL.jpg”,”brand”:{“@type”:”Brand”,”name”:”Eucerin”},”review”:{“@type”:”Review”,”name”:”Immersive Hydration Moisture Boost Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1708532975-71-lEoEV8ZL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”According to the pros, hyaluronic acid is a key ingredient to look for in wrinkle fillers (there’s a reason it’s the main ingredient in in-office dermal fillers!). “This serum delivers two forms of hyaluronic acid, both low and high molecular weight, to hydrate, smooth, and fill the skin both deep in the skin and at the surface,” Dr. Zeichner explains. In addition to containing a highly concentrated form of hyaluronic acid, this lightweight is also non-comedogenic (meaning it won’t clog pores) and is suitable for all skin types, including sensitive skin.What a reviewer says: “I was excited to try a serum as someone who is always looking for the fountain of youth for anti-aging. Hyaluronic acid is one of the most important ingredients in my opinion for dulling fine lines and wrinkles,” said one shopper. “This serum has a light, clean scent that I enjoyed. The gel is thick enough that it applies evenly and absorbs quickly. I found my skin to be surprisingly soft after using. In fact, I didn’t necessarily even need a moisturizer and will often use it on its own after cleansing. This may be one of the most impactful serums I’ve used!””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Lightweight formula”},{“@type”:”ListItem”,”position”:”2″,”name”:”Hydrates and plumps skin with hyaluronic acid”},{“@type”:”ListItem”,”position”:”3″,”name”:”Suitable for sensitive skin “}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Some reviewers say it feels a bit tacky on the skin “}]}}}},{“@type”:”ListItem”,”position”:3,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”P-TIOX Anti-Wrinkle Peptide Serum”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-3″,”description”:”“This peptide-containing serum has been shown to reduce the appearance of expression lines,” says Dr. Garshick. “In addition to peptides, it also contains PHA, niacinamide, and laminaria extract which also helps to improve radiance. It can be used alone or as a complement to Botox injections to smooth the appearance of fine lines.” The brand says it’s clinically proven to diminish the look of nine types of expression lines—including forehead wrinkles, crow’s feet, and more—while also improving smoothness, refining the look of pores, and promoting “glass skin” radiance. What a reviewer says: “This has been the holy grail for my skin. Within a week of use my skin was GORGEOUS. Glowy, clear, tighter,” raved one 42-year-old Dermstore customer. “I even had a reduction in breakouts…and my fine lines were less visible. Every time I put on this serum, I felt like I was applying a real-life filter to my face. I pray to the skin gods that this product continues forever.””,”image”:”https://vader-prod.s3.amazonaws.com/1770928293-images-3-698e37ff73696.jpg”,”brand”:{“@type”:”Brand”,”name”:”Skinceuticals”},”review”:{“@type”:”Review”,”name”:”P-TIOX Anti-Wrinkle Peptide Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1770928293-images-3-698e37ff73696.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”“This peptide-containing serum has been shown to reduce the appearance of expression lines,” says Dr. Garshick. “In addition to peptides, it also contains PHA, niacinamide, and laminaria extract which also helps to improve radiance. It can be used alone or as a complement to Botox injections to smooth the appearance of fine lines.” The brand says it’s clinically proven to diminish the look of nine types of expression lines—including forehead wrinkles, crow’s feet, and more—while also improving smoothness, refining the look of pores, and promoting “glass skin” radiance. What a reviewer says: “This has been the holy grail for my skin. Within a week of use my skin was GORGEOUS. Glowy, clear, tighter,” raved one 42-year-old Dermstore customer. “I even had a reduction in breakouts…and my fine lines were less visible. Every time I put on this serum, I felt like I was applying a real-life filter to my face. I pray to the skin gods that this product continues forever.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Targets nine types of expression lines”},{“@type”:”ListItem”,”position”:”2″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”3″,”name”:”Promotes radiance”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey”}]}}}},{“@type”:”ListItem”,”position”:4,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Liquid Peptides Advanced MP Face Serum”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-4″,”description”:”“This peptide serum combines multiple peptides and has been shown to reduce the appearance of expression lines in 10 minutes and deep-set wrinkles over the course of eight weeks,” says Dr. Garshick. With a potent formulation of 30% multi-peptide complex that contains 13 different peptides, it also utilizes an innovative peptide technology to target fine lines and wrinkles for both short-term and long-term results. “It combines Dual MiniProteins, including an expression line miniprotein and a growth factor miniprotein, to help address signs of aging,” Dr. Garshick explains. What a reviewer says: “The best peptide serum I’ve tried…I really love this serum, it actually works! The peptides it contains are the absolute best for anti-aging skincare…I find this to be non-greasy, lightly moisturizing, and absorbs quickly which is a huge plus,” a shopper wrote. “I’m almost 48 and this has really improved my fine lines and I feel like it’s firmed my skin up and my skin tone seems a lot more even as well. It really does what they say it will do which to me makes it worth the higher price tag.””,”image”:”https://vader-prod.s3.amazonaws.com/1770929295-51Mi6MfKYlL.jpg”,”brand”:{“@type”:”Brand”,”name”:”Medik8″},”review”:{“@type”:”Review”,”name”:”Liquid Peptides Advanced MP Face Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1770929295-51Mi6MfKYlL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”“This peptide serum combines multiple peptides and has been shown to reduce the appearance of expression lines in 10 minutes and deep-set wrinkles over the course of eight weeks,” says Dr. Garshick. With a potent formulation of 30% multi-peptide complex that contains 13 different peptides, it also utilizes an innovative peptide technology to target fine lines and wrinkles for both short-term and long-term results. “It combines Dual MiniProteins, including an expression line miniprotein and a growth factor miniprotein, to help address signs of aging,” Dr. Garshick explains. What a reviewer says: “The best peptide serum I’ve tried…I really love this serum, it actually works! The peptides it contains are the absolute best for anti-aging skincare…I find this to be non-greasy, lightly moisturizing, and absorbs quickly which is a huge plus,” a shopper wrote. “I’m almost 48 and this has really improved my fine lines and I feel like it’s firmed my skin up and my skin tone seems a lot more even as well. It really does what they say it will do which to me makes it worth the higher price tag.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Targets expression lines and deep-set wrinkles”},{“@type”:”ListItem”,”position”:”2″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”3″,”name”:”Both short-term and long-term results”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey”}]}}}},{“@type”:”ListItem”,”position”:5,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Instant Illusion Wrinkle Filler”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-5″,”description”:”If you’re looking for instant results or a “quick fix,” Dr. Garshick recommends this affordable serum from No 7 that promises an “instant illusion” to leave skin looking smoother and more youthful. “This at-home treatment uses glycerin and light-diffusing particles, which blurs the appearance of fine lines and wrinkles without irritating the skin,” she explains. Plus: It comes in a lightweight, velvety-soft formula that’s free of fragrance, parabens, and sulfates. What a reviewer says: “I think it works very well for a quick temporary fix. It definitely helps smooth out any fine lines or wrinkles. I’m a bit self conscious of my ‘elevens’ between my eyes but this helps blur the lines right before my eyes,” said one reviewer. “I wear it with and without makeup. Start with a little because it is build able and if you put too much on it can leave a a slight white film. I have it in my purse at all times in case of needing a touch up. Definitely worth it if you don’t have the means to splurge on Botox.””,”image”:”https://vader-prod.s3.amazonaws.com/1708533402-41pGe8VUoGL.jpg”,”brand”:{“@type”:”Brand”,”name”:”No7″},”review”:{“@type”:”Review”,”name”:”Instant Illusion Wrinkle Filler”,”image”:”https://vader-prod.s3.amazonaws.com/1708533402-41pGe8VUoGL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”If you’re looking for instant results or a “quick fix,” Dr. Garshick recommends this affordable serum from No 7 that promises an “instant illusion” to leave skin looking smoother and more youthful. “This at-home treatment uses glycerin and light-diffusing particles, which blurs the appearance of fine lines and wrinkles without irritating the skin,” she explains. Plus: It comes in a lightweight, velvety-soft formula that’s free of fragrance, parabens, and sulfates. What a reviewer says: “I think it works very well for a quick temporary fix. It definitely helps smooth out any fine lines or wrinkles. I’m a bit self conscious of my ‘elevens’ between my eyes but this helps blur the lines right before my eyes,” said one reviewer. “I wear it with and without makeup. Start with a little because it is build able and if you put too much on it can leave a a slight white film. I have it in my purse at all times in case of needing a touch up. Definitely worth it if you don’t have the means to splurge on Botox.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Lightweight formula”},{“@type”:”ListItem”,”position”:”2″,”name”:”Blurs appearance of fine lines and wrinkles”},{“@type”:”ListItem”,”position”:”3″,”name”:”Hydrates and plumps skin with glycerin”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Effects are mostly temporary”}]}}}},{“@type”:”ListItem”,”position”:6,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”ExLinea Peptide Smoothing Face Serum”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-6″,”description”:”This peptide spot treatment specifically targets expression lines and areas of wrinkles and sagging, helping to hydrate, smooth, and firm aging skin. “Containing a blend of argireline, hyaluronic acid and squalene, this helps to improve the appearance of fine lines and wrinkles,” Dr. Garshick says (argireline is a peptide that reduces and relaxes muscle contractions to minimize fine lines and wrinkles, according to the brand). “It is best to apply 1-2 pumps to areas of wrinkling and sagging, especially on the lines around the eyes, forehead and mouth,” notes Dr. Garshick. What a reviewer says: “I have used many products but this is the first product that has noticeably reversed the aging process,” one shopper wrote. “I was starting to see fine lines on my cheeks when I smiled. I have been using this product for about 3 months and just noticed that those have completely disappeared. It is pricey but a little dot goes along way. This product has lasted a long time. I’m still on my first bottle and have quite a bit left.””,”image”:”https://vader-prod.s3.amazonaws.com/1771341931-61VAndPgDXL.jpg”,”brand”:{“@type”:”Brand”,”name”:”PCA Skin”},”review”:{“@type”:”Review”,”name”:”ExLinea Peptide Smoothing Face Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1771341931-61VAndPgDXL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”This peptide spot treatment specifically targets expression lines and areas of wrinkles and sagging, helping to hydrate, smooth, and firm aging skin. “Containing a blend of argireline, hyaluronic acid and squalene, this helps to improve the appearance of fine lines and wrinkles,” Dr. Garshick says (argireline is a peptide that reduces and relaxes muscle contractions to minimize fine lines and wrinkles, according to the brand). “It is best to apply 1-2 pumps to areas of wrinkling and sagging, especially on the lines around the eyes, forehead and mouth,” notes Dr. Garshick. What a reviewer says: “I have used many products but this is the first product that has noticeably reversed the aging process,” one shopper wrote. “I was starting to see fine lines on my cheeks when I smiled. I have been using this product for about 3 months and just noticed that those have completely disappeared. It is pricey but a little dot goes along way. This product has lasted a long time. I’m still on my first bottle and have quite a bit left.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Targets expression lines and wrinkles”},{“@type”:”ListItem”,”position”:”2″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”3″,”name”:”Hydrates and plumps skin with hyaluronic acid and squalene”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey”}]}}}},{“@type”:”ListItem”,”position”:7,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Interfuse Treatment Cream Eye”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-7″,”description”:”If you’re not quite ready to experiment with or invest in botox, Dr. Mraz suggests this eye cream treatment that targets wrinkles, puffiness, and under-eye darkness. “The skin around our eyes is unique, so seeking a targeted product for this area is important. The skin around the eyes is thinner and naturally has less collagen and sebaceous glands,” he explains. “[For crow’s feet] I really like Skinbetter Science’s Interfuse Eyes. While nothing can replace the ‘real deal’ when it comes to toxin, this formula includes niacinamide and caffeine which help depuff and smooth the skin.” Peptides also help smooth wrinkles, while hyaluronic acid delivers moisture and vitamin C helps brighten under-eye darkness. What a reviewer says: “Perhaps the best eye cream I have tried to date…HOLY COW does this stuff work!” raved one reviewer. “The tightness of the cream for your crow’s feet and brow bone (I even put it in between my eyebrows for my eleven lines, and I feel like it totally helped) was far beyond my expectation of what it could do…It goes on so smoothly, with no issues of oiliness! The little pump gives you the perfect amount!” “,”image”:”https://vader-prod.s3.amazonaws.com/1737045395-858970006009-Hero-1.jpg”,”brand”:{“@type”:”Brand”,”name”:”Skinbetter Science”},”review”:{“@type”:”Review”,”name”:”Interfuse Treatment Cream Eye”,”image”:”https://vader-prod.s3.amazonaws.com/1737045395-858970006009-Hero-1.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”If you’re not quite ready to experiment with or invest in botox, Dr. Mraz suggests this eye cream treatment that targets wrinkles, puffiness, and under-eye darkness. “The skin around our eyes is unique, so seeking a targeted product for this area is important. The skin around the eyes is thinner and naturally has less collagen and sebaceous glands,” he explains. “[For crow’s feet] I really like Skinbetter Science’s Interfuse Eyes. While nothing can replace the ‘real deal’ when it comes to toxin, this formula includes niacinamide and caffeine which help depuff and smooth the skin.” Peptides also help smooth wrinkles, while hyaluronic acid delivers moisture and vitamin C helps brighten under-eye darkness. What a reviewer says: “Perhaps the best eye cream I have tried to date…HOLY COW does this stuff work!” raved one reviewer. “The tightness of the cream for your crow’s feet and brow bone (I even put it in between my eyebrows for my eleven lines, and I feel like it totally helped) was far beyond my expectation of what it could do…It goes on so smoothly, with no issues of oiliness! The little pump gives you the perfect amount!” “,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”2″,”name”:”Hydrates and plumps skin with hyaluronic acid”},{“@type”:”ListItem”,”position”:”3″,”name”:”Also targets puffiness and under-eye darkness”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey for the amount”}]}}}},{“@type”:”ListItem”,”position”:8,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Needle-less Serum”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-8″,”description”:”“This twice-daily serum contains a blend of peptides (including copper peptides), ceramides, niacinamide, and hyaluronic acid to improve the overall appearance of fine lines and wrinkles while also strengthening the skin’s moisture barrier,” explains Dr. Garshick. Fragrance-free and fast-absorbing, the formula also delivers deep hydration and targets dullness and redness while visibly smoothing and plumping fine lines. What a reviewer says: “No more Botox after trying this! I’ve tried all types of anti-aging serums…Some worked okay but nothing has shown results quite like the Needle-less Serum,” a shopper said. “I initially bought it to reduce the fine lines around my forehead, but after daily use, I noticed my dark spots/hyperpigmentation started fading too! I am so shocked by how well this serum has worked for me. I was thinking about getting Botox, but after trying this, I honestly think I can wait a few more years…It’s by far the best serum I’ve ever used for fine lines.””,”image”:”https://vader-prod.s3.amazonaws.com/1698339290-51xqQJ6yzAL.jpg”,”brand”:{“@type”:”Brand”,”name”:”DRMTLGY”},”review”:{“@type”:”Review”,”name”:”Needle-less Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1698339290-51xqQJ6yzAL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”“This twice-daily serum contains a blend of peptides (including copper peptides), ceramides, niacinamide, and hyaluronic acid to improve the overall appearance of fine lines and wrinkles while also strengthening the skin’s moisture barrier,” explains Dr. Garshick. Fragrance-free and fast-absorbing, the formula also delivers deep hydration and targets dullness and redness while visibly smoothing and plumping fine lines. What a reviewer says: “No more Botox after trying this! I’ve tried all types of anti-aging serums…Some worked okay but nothing has shown results quite like the Needle-less Serum,” a shopper said. “I initially bought it to reduce the fine lines around my forehead, but after daily use, I noticed my dark spots/hyperpigmentation started fading too! I am so shocked by how well this serum has worked for me. I was thinking about getting Botox, but after trying this, I honestly think I can wait a few more years…It’s by far the best serum I’ve ever used for fine lines.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”2″,”name”:”Hydrates and plumps with hyaluronic acid and ceramides”},{“@type”:”ListItem”,”position”:”3″,”name”:”Also targets dullness and redness “}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Some reviewers noted irritation on sensitive skin”}]}}}},{“@type”:”ListItem”,”position”:9,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Regenerist Micro-Sculpting Cream”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-9″,”description”:”Crowned our best overall wrinkle cream, this best-selling Olay pick earned previous approval from Debra Jaliman, M.D., a board-certified dermatologist in New York City, who noted that it contains hyaluronic acid to plump and hydrate, amino peptides to firm, and niacinamide to improve the appearance of enlarged pores and dullness. The newly upgraded formula also contains triple collagen peptide to firm, smooth, and tighten skin. What a reviewer says: “I’ve been using this face cream for about four years and I love it! It keeps my skin hydrated, it doesn’t seem to clog my pores, and I swear it has kept the wrinkles at bay,” wrote one Amazon shopper. “I’m in my mid-40s and people always tell me I look younger. In fact, I really don’t have any wrinkles at all and I think this cream has helped with that!” “,”image”:”https://vader-prod.s3.amazonaws.com/1771347365-71exy6431wl-sl1500-69949d8e1dc11.jpg”,”brand”:{“@type”:”Brand”,”name”:”Olay”},”review”:{“@type”:”Review”,”name”:”Regenerist Micro-Sculpting Cream”,”image”:”https://vader-prod.s3.amazonaws.com/1771347365-71exy6431wl-sl1500-69949d8e1dc11.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”Crowned our best overall wrinkle cream, this best-selling Olay pick earned previous approval from Debra Jaliman, M.D., a board-certified dermatologist in New York City, who noted that it contains hyaluronic acid to plump and hydrate, amino peptides to firm, and niacinamide to improve the appearance of enlarged pores and dullness. The newly upgraded formula also contains triple collagen peptide to firm, smooth, and tighten skin. What a reviewer says: “I’ve been using this face cream for about four years and I love it! It keeps my skin hydrated, it doesn’t seem to clog my pores, and I swear it has kept the wrinkles at bay,” wrote one Amazon shopper. “I’m in my mid-40s and people always tell me I look younger. In fact, I really don’t have any wrinkles at all and I think this cream has helped with that!” “,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”2″,”name”:”Hydrates and plumps skin with hyaluronic acid”},{“@type”:”ListItem”,”position”:”3″,”name”:”Fast-absorbing cream texture”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Thicker formula may not be great for oily skin types”}]}}}},{“@type”:”ListItem”,”position”:10,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Invisible UV Flawless Primer SPF 50″,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-10″,”description”:”If you’re looking for a primer to smooth out wrinkles under makeup, this popular pick from Charlotte Tilbury comes recommended by Dr. Zeichner. He recommends the “multitasking” primer not only for its ability to “hydrate, plump, and minimize the appearance of lines” with hyaluronic acid, but also for its ability to protect the skin from UV rays and environmental aggressors. “Plus it forms a smooth canvas for makeup,” he adds.What a reviewer says: “I love Charlotte Tilbury’s broad spectrum SPF 50 sunscreen primer because it’s is lightweight and goes on smoothly,” said one shopper. “I love the primer because not only is it hydrating, it also has a great blurring effect that tends to make my pores look smaller, and blurring helps minimize my superficial wrinkles. I also have rosacea, and this does not irritate it in any way…I recommend this for anyone who wants a primer, a great sunburn preventative, and a blurring effect to make skin look healthier and younger.””,”image”:”https://vader-prod.s3.amazonaws.com/1745806450-1715022185-1661272417-ct-1661272398.png”,”brand”:{“@type”:”Brand”,”name”:”Charlotte Tilbury”},”review”:{“@type”:”Review”,”name”:”Invisible UV Flawless Primer SPF 50″,”image”:”https://vader-prod.s3.amazonaws.com/1745806450-1715022185-1661272417-ct-1661272398.png”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”If you’re looking for a primer to smooth out wrinkles under makeup, this popular pick from Charlotte Tilbury comes recommended by Dr. Zeichner. He recommends the “multitasking” primer not only for its ability to “hydrate, plump, and minimize the appearance of lines” with hyaluronic acid, but also for its ability to protect the skin from UV rays and environmental aggressors. “Plus it forms a smooth canvas for makeup,” he adds.What a reviewer says: “I love Charlotte Tilbury’s broad spectrum SPF 50 sunscreen primer because it’s is lightweight and goes on smoothly,” said one shopper. “I love the primer because not only is it hydrating, it also has a great blurring effect that tends to make my pores look smaller, and blurring helps minimize my superficial wrinkles. I also have rosacea, and this does not irritate it in any way…I recommend this for anyone who wants a primer, a great sunburn preventative, and a blurring effect to make skin look healthier and younger.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Hydrates and plumps skin with hyaluronic acid”},{“@type”:”ListItem”,”position”:”2″,”name”:”Primes skin for makeup “},{“@type”:”ListItem”,”position”:”3″,”name”:”SPF 50 protects skin from UV rays and sun damage”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey”}]}}}},{“@type”:”ListItem”,”position”:11,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Deep Wrinkle Dermal Filler”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-11″,”description”:”Dr. Garshick also recommends this hydrating serum from Andalou Naturals which contains powerful actives that helps support skin cell energy for smoother, softer skin. “This serum combines heirloom apple and grape stem cells which are rich in antioxidants, coenzyme Q10 which also helps to smooth the skin, and goji glycopeptides which help to firm and lift the skin,” she says. “It helps hydrate and smooth the skin, improving the appearance of fine lines and wrinkles.”What a reviewer says: “Absolutely amazing…I am VERY pleased with how well it works. I used it on my ‘kissy wrinkles’ around my lips and I could hardly believe the results!” one reviewer shared. “I like the way it seems to hydrate my skin, as well as filling in the lines around my mouth. I also used it on the furrows between my eyes with great results. I will absolutely purchase this product again.””,”image”:”https://vader-prod.s3.amazonaws.com/1770929471-51mnwqibdel-sl1500-698e3d2826818.jpg”,”brand”:{“@type”:”Brand”,”name”:”Andalou Naturals”},”review”:{“@type”:”Review”,”name”:”Deep Wrinkle Dermal Filler”,”image”:”https://vader-prod.s3.amazonaws.com/1770929471-51mnwqibdel-sl1500-698e3d2826818.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”Dr. Garshick also recommends this hydrating serum from Andalou Naturals which contains powerful actives that helps support skin cell energy for smoother, softer skin. “This serum combines heirloom apple and grape stem cells which are rich in antioxidants, coenzyme Q10 which also helps to smooth the skin, and goji glycopeptides which help to firm and lift the skin,” she says. “It helps hydrate and smooth the skin, improving the appearance of fine lines and wrinkles.”What a reviewer says: “Absolutely amazing…I am VERY pleased with how well it works. I used it on my ‘kissy wrinkles’ around my lips and I could hardly believe the results!” one reviewer shared. “I like the way it seems to hydrate my skin, as well as filling in the lines around my mouth. I also used it on the furrows between my eyes with great results. I will absolutely purchase this product again.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”2″,”name”:”Rich in antixoidants”},{“@type”:”ListItem”,”position”:”3″,”name”:”Lightweight and soothing formula”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Comes in a small tube”},{“@type”:”ListItem”,”position”:”2″,”name”:”Not fragrance-free”}]}}}},{“@type”:”ListItem”,”position”:12,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”DermInfusions Fill + Repair Serum”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-12″,”description”:”Formulated with peptides, hyaluronic acid, niacinamide, and ectoin, this serum helps to “fill lines” and “boost moisture and volume,” according to Dr. Garshick. Four different sizes of hyaluronic acid penetrate the skin at different levels to plump and hydrate, while peptides visibly firm and lift the skin—plus, niacinamide and ectoin helps reduce redness and strengthen the skin barrier. It’s also formulated to provide both immediate and long-term results.What a reviewer says: “I’m impressed with how lightweight this moisturizing lotion is. It goes on smoothly and gets absorbed by the skin in no time,” one customer shared. “It’s great for sensitive skin and a great choice for moisturizing my face. Since I’ve been using it regularly for a few weeks now, I’ve noticed a remarkable difference in how smooth and healthy my skin looks and feels. I couldn’t be happier with the results.””,”image”:”https://vader-prod.s3.amazonaws.com/1767979200-1709748040-1701186397-grosswerum-65660b56cd394.jpg”,”brand”:{“@type”:”Brand”,”name”:”Dr. Dennis Gross”},”review”:{“@type”:”Review”,”name”:”DermInfusions Fill + Repair Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1767979200-1709748040-1701186397-grosswerum-65660b56cd394.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”Formulated with peptides, hyaluronic acid, niacinamide, and ectoin, this serum helps to “fill lines” and “boost moisture and volume,” according to Dr. Garshick. Four different sizes of hyaluronic acid penetrate the skin at different levels to plump and hydrate, while peptides visibly firm and lift the skin—plus, niacinamide and ectoin helps reduce redness and strengthen the skin barrier. It’s also formulated to provide both immediate and long-term results.What a reviewer says: “I’m impressed with how lightweight this moisturizing lotion is. It goes on smoothly and gets absorbed by the skin in no time,” one customer shared. “It’s great for sensitive skin and a great choice for moisturizing my face. Since I’ve been using it regularly for a few weeks now, I’ve noticed a remarkable difference in how smooth and healthy my skin looks and feels. I couldn’t be happier with the results.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”2″,”name”:”Hydrates and plumps skin with hyaluronic acid”},{“@type”:”ListItem”,”position”:”3″,”name”:”Helps reduce redness”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Not fragrance-free; some reviewers dislike the scent”}]}}}},{“@type”:”ListItem”,”position”:13,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”YouthBomb 360° Radiance Concentrate Serum”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-13″,”description”:”This serum delivers heaps of skin-loving ingredients for glowing, younger-looking your skin, including hyaluronic acid—which Dr. Zeichner says “fills and plumps” as well as peptides to help “strengthen the skin.” It also contains other powerful humectants for hydrating and plumping the skin, like glycerin and polyglutamic acid. In addition to reducing the appearance of fine lines, the serum is also formulated to brighten skin and boost elasticity within the skin.What a reviewer says: “I have been using YouthBomb products for over a year now and my skin has never looked better. I live in a dry high mountain climate which accentuates wrinkles and dryness. With these products that issue is solved, as well as my skin texture is smooth and even, wrinkles reduced, and plumpness are greatly improved,” one customer shared. “I never have breakouts from the products and feel comfortable that my skin glows without any makeup. When I do wear foundation it adheres smoothly. I recommend these highly.””,”image”:”https://vader-prod.s3.amazonaws.com/1701081763-OTF20BETA-youthbomb_radiance_serum_194765_CSL_secondary_WEB.jpg”,”brand”:{“@type”:”Brand”,”name”:”Beautypie”},”review”:{“@type”:”Review”,”name”:”YouthBomb 360° Radiance Concentrate Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1701081763-OTF20BETA-youthbomb_radiance_serum_194765_CSL_secondary_WEB.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”This serum delivers heaps of skin-loving ingredients for glowing, younger-looking your skin, including hyaluronic acid—which Dr. Zeichner says “fills and plumps” as well as peptides to help “strengthen the skin.” It also contains other powerful humectants for hydrating and plumping the skin, like glycerin and polyglutamic acid. In addition to reducing the appearance of fine lines, the serum is also formulated to brighten skin and boost elasticity within the skin.What a reviewer says: “I have been using YouthBomb products for over a year now and my skin has never looked better. I live in a dry high mountain climate which accentuates wrinkles and dryness. With these products that issue is solved, as well as my skin texture is smooth and even, wrinkles reduced, and plumpness are greatly improved,” one customer shared. “I never have breakouts from the products and feel comfortable that my skin glows without any makeup. When I do wear foundation it adheres smoothly. I recommend these highly.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Hydrates and plumps skin with hyaluronic acid”},{“@type”:”ListItem”,”position”:”2″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”3″,”name”:”Boosts radiance and elasticity “}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Some reviewers report issues with the dropper”}]}}}},{“@type”:”ListItem”,”position”:14,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Revox Line Relaxer”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-14″,”description”:”Dr. Garshick recommends this advanced, targeted serum for its ability to “reduce the appearance of expression lines” with a patent-pending blend of peptides as well as “plump the skin” and reduce dryness with hyaluronic acid. “It can be used twice daily and should be massaged into any area of fine lines and wrinkles,” she adds. It’s formulated to visibly reduce expression lines, fine lines, wrinkles, and pore size with a blend of peptides and collagen-supporting ingredients, while also supporting a balanced microbiome for healthier skin.What a reviewer says: “I am 58 years old and stopped using Botox five years ago. Since stopping, I have had a lot of deep wrinkles around my eyes and forehead,” shared one shopper. “I was reluctant to invest a lot of money on a product like this, but I am seeing some dramatic results. Yes, the wrinkles are still there, but the creases are much smaller, finer, and I think are suitable for a woman my age.” “,”image”:”https://vader-prod.s3.amazonaws.com/1771349606-61WFzNMQgNL.jpg”,”brand”:{“@type”:”Brand”,”name”:”Revision Skincare”},”review”:{“@type”:”Review”,”name”:”Revox Line Relaxer”,”image”:”https://vader-prod.s3.amazonaws.com/1771349606-61WFzNMQgNL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shannen Zitz”},{“@type”:”Person”,”name”:”Charlotte Lewis Finigan”}],”reviewBody”:”Dr. Garshick recommends this advanced, targeted serum for its ability to “reduce the appearance of expression lines” with a patent-pending blend of peptides as well as “plump the skin” and reduce dryness with hyaluronic acid. “It can be used twice daily and should be massaged into any area of fine lines and wrinkles,” she adds. It’s formulated to visibly reduce expression lines, fine lines, wrinkles, and pore size with a blend of peptides and collagen-supporting ingredients, while also supporting a balanced microbiome for healthier skin.What a reviewer says: “I am 58 years old and stopped using Botox five years ago. Since stopping, I have had a lot of deep wrinkles around my eyes and forehead,” shared one shopper. “I was reluctant to invest a lot of money on a product like this, but I am seeing some dramatic results. Yes, the wrinkles are still there, but the creases are much smaller, finer, and I think are suitable for a woman my age.” “,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Targets expression lines, wrinkles, and pore size”},{“@type”:”ListItem”,”position”:”2″,”name”:”Firms and smooths skin with peptides”},{“@type”:”ListItem”,”position”:”3″,”name”:”Hydrates and plumps skin with hyaluronic acid and glycerin”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey”}]}}}},{“@type”:”ListItem”,”position”:15,”item”:{“name”:”Do wrinkle fillers really work?”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-15″,”description”:”While at-home (topical) products can certainly do wonders in improving the appearance of wrinkles, “the effect is generally considered temporary,” Dr. Garshick explains. However, certain ingredients that have been shown to boost collagen production (like retinol and peptides) may be beneficial in improving the appearance of wrinkles long-term, she adds.“When used regularly, topical wrinkle serums can be effective at improving wrinkles and preventing new ones,” Dr. Mraz agrees. “However, they can be most effective when paired with treatments such as lasers and injectable neuromodulators.” In other words: Don’t expect your at-home creams and serums to have the same level of effectiveness as in-office treatments. “,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”}},{“@type”:”ListItem”,”position”:16,”item”:{“name”:”How long do wrinkle fillers last?”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-16″,”description”:”Generally, the effects of topical wrinkle fillers are temporary. According to Dr. Garshick, wrinkle fillers with ingredients like silicones or film-forming agents typically provide temporary wrinkle-smoothing benefits that only last several hours or until you wash your face. Formulas that “contain active ingredients like peptides, retinoids, or growth factors can lead to more lasting improvement, but these results develop gradually with consistent use over weeks to months,” she explains. All in all: “It’s important to set realistic expectations as topical wrinkle fillers can improve the appearance of fine lines, but do not necessarily replace in-office treatments, especially for deeper wrinkles,” Dr. Garshick says. “,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”}},{“@type”:”ListItem”,”position”:17,”item”:{“name”:”What is the best way to apply wrinkle filler? “,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-17″,”description”:”The best way to apply a wrinkle filler generally depends on the specific formulation of the product, says Dr. Garshick. “For serums it is best to apply to the skin after cleansing and prior to moisturizing, while for cream-based formulations it may be best to apply as a last step in an evening routine or just prior to sunscreen in a morning routine,” she explains. “For best results, it should be used daily and it is recommended to follow package instructions, as some may be intended for the lines specifically while others may be applied to the whole face.””,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”}},{“@type”:”ListItem”,”position”:18,”item”:{“name”:”How to choose the best wrinkle fillers”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-18″,”description”:”Experts recommend looking for the following ingredients in at-home wrinkle fillers:✔️ Hyaluronic acid. This ultra-hydrating ingredient helps “to draw moisture in and works to plump the skin,” Dr. Garshick says.✔️ Retinol. Retinol has been proven to prevent and address visible signs of aging, including fine lines and wrinkles, for its ability to regulate skin cell turnover and boost collagen production.✔️ Bakuchiol. For those who are sensitive to retinol, bakuchiol is a great plant-based alternative that can also improve the appearance of fines lines and wrinkles—but often with less irritation, according to Dr. Garshick. ✔️ Peptides. Like retinol, peptides help boost collagen. In doing so, peptide serums and creams can help plump the skin and reduce the appearance of fine lines and wrinkles.✔️ Niacinamide. A form of vitamin B3, this ingredient “helps strengthen the skin barrier, improve tone and texture, and reduce inflammation, making skin appear smoother and more even,” explains Dr. Garshick. ✔️ Antioxidants. “These protect against free radical damage from UV exposure and pollution, which contribute to premature aging,” Dr. Garshick says. “Vitamin C in particular can help brighten the skin and support collagen synthesis.”✔️ Growth factors. Growth factors are proteins that help to naturally repair the skin. These help support collagen production and skin repair to improve the appearance of fine lines over time, according to experts. ✔️ Silicones and light-diffusing particles. “While not treating wrinkles long term, these ingredients can provide an immediate blurring and smoothing effect, which is helpful for instant cosmetic improvement,” explains Dr. Garshick. “,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”}},{“@type”:”ListItem”,”position”:19,”item”:{“name”:”How we chose the best wrinkle fillers”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-19″,”description”:”We spoke with Joshua Zeichner, M.D., a board-certified dermatologist and director of cosmetic and clinical research in dermatology at the Mount Sinai Medical Center in NYC; Deanne Mraz, M.D., F.A.A.D., board-certified dermatologist, President and Co-Founder of Modern Dermatology of Connecticut; and Marisa Garshick, M.D., a board-certified dermatologist at MDCS Dermatology in NYC. We also pored through countless product reviews, ratings, and specs to select the best wrinkle fillers available.”,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”}},{“@type”:”ListItem”,”position”:20,”item”:{“name”:”Why trust us”,”url”:”https://www.prevention.com/beauty/skin-care/g70314262/best-wrinkle-fillers-guide/#slide-20″,”description”:”For more than 70 years, Prevention has been a leading provider of trustworthy health information, empowering readers with practical strategies to improve their physical, mental, and emotional well-being. Our editors interview medical experts to help guide our health-focused product selections. Additionally, Prevention also examines hundreds of reviews—and often conducts personal testing done by our staff—to help you make informed decisions.”,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”}}]}}]
“This peptide-containing serum has been shown to reduce the appearance of expression lines,” says Dr. Garshick. “In addition to peptides, it also contains PHA, niacinamide, and laminaria extract which also helps to improve radiance. It can be used alone or as a complement to Botox injections to smooth the appearance of fine lines.” The brand says it’s clinically proven to diminish the look of nine types of expression lines—including forehead wrinkles, crow’s feet, and more—while also improving smoothness, refining the look of pores, and promoting “glass skin” radiance.
What a reviewer says: “This has been the holy grail for my skin. Within a week of use my skin was GORGEOUS. Glowy, clear, tighter,” raved one 42-year-old Dermstore customer. “I even had a reduction in breakouts…and my fine lines were less visible. Every time I put on this serum, I felt like I was applying a real-life filter to my face. I pray to the skin gods that this product continues forever.”
Features at a Glance
| Key ingredients | Advanced peptide complex, PHA, niacinamide, laminaria extract |
| Size | 1 fl oz |
| Fragrance-free | Yes |
“This peptide serum combines multiple peptides and has been shown to reduce the appearance of expression lines in 10 minutes and deep-set wrinkles over the course of eight weeks,” says Dr. Garshick. With a potent formulation of 30% multi-peptide complex that contains 13 different peptides, it also utilizes an innovative peptide technology to target fine lines and wrinkles for both short-term and long-term results. “It combines Dual MiniProteins, including an expression line miniprotein and a growth factor miniprotein, to help address signs of aging,” Dr. Garshick explains.
What a reviewer says: “The best peptide serum I’ve tried…I really love this serum, it actually works! The peptides it contains are the absolute best for anti-aging skincare…I find this to be non-greasy, lightly moisturizing, and absorbs quickly which is a huge plus,” a shopper wrote. “I’m almost 48 and this has really improved my fine lines and I feel like it’s firmed my skin up and my skin tone seems a lot more even as well. It really does what they say it will do which to me makes it worth the higher price tag.”
Features at a Glance
| Key ingredients | Peptides, growth factor miniprotein, expression line miniprotein |
| Size | 1 fl oz |
| Fragrance-free | Yes |
This peptide spot treatment specifically targets expression lines and areas of wrinkles and sagging, helping to hydrate, smooth, and firm aging skin. “Containing a blend of argireline, hyaluronic acid and squalene, this helps to improve the appearance of fine lines and wrinkles,” Dr. Garshick says (argireline is a peptide that reduces and relaxes muscle contractions to minimize fine lines and wrinkles, according to the brand). “It is best to apply 1-2 pumps to areas of wrinkling and sagging, especially on the lines around the eyes, forehead and mouth,” notes Dr. Garshick.
What a reviewer says: “I have used many products but this is the first product that has noticeably reversed the aging process,” one shopper wrote. “I was starting to see fine lines on my cheeks when I smiled. I have been using this product for about 3 months and just noticed that those have completely disappeared. It is pricey but a little dot goes along way. This product has lasted a long time. I’m still on my first bottle and have quite a bit left.”
Features at a Glance
| Key ingredients | Cetyl hexapeptide-8 (argireline), hyaluronic acid, squalene |
| Size | 1 fl oz |
| Fragrance-free | Yes |
If you’re looking for a primer to smooth out wrinkles under makeup, this popular pick from Charlotte Tilbury comes recommended by Dr. Zeichner. He recommends the “multitasking” primer not only for its ability to “hydrate, plump, and minimize the appearance of lines” with hyaluronic acid, but also for its ability to protect the skin from UV rays and environmental aggressors. “Plus it forms a smooth canvas for makeup,” he adds.
What a reviewer says: “I love Charlotte Tilbury’s broad spectrum SPF 50 sunscreen primer because it’s is lightweight and goes on smoothly,” said one shopper. “I love the primer because not only is it hydrating, it also has a great blurring effect that tends to make my pores look smaller, and blurring helps minimize my superficial wrinkles. I also have rosacea, and this does not irritate it in any way…I recommend this for anyone who wants a primer, a great sunburn preventative, and a blurring effect to make skin look healthier and younger.”
Features at a Glance
| Key ingredients | Hyaluronic acid, vitamin C, vitamin E, SPF |
| Size | 1 fl oz |
| Fragrance-free | Yes |
Dr. Garshick also recommends this hydrating serum from Andalou Naturals which contains powerful actives that helps support skin cell energy for smoother, softer skin. “This serum combines heirloom apple and grape stem cells which are rich in antioxidants, coenzyme Q10 which also helps to smooth the skin, and goji glycopeptides which help to firm and lift the skin,” she says. “It helps hydrate and smooth the skin, improving the appearance of fine lines and wrinkles.”
What a reviewer says: “Absolutely amazing…I am VERY pleased with how well it works. I used it on my ‘kissy wrinkles’ around my lips and I could hardly believe the results!” one reviewer shared. “I like the way it seems to hydrate my skin, as well as filling in the lines around my mouth. I also used it on the furrows between my eyes with great results. I will absolutely purchase this product again.”
| Key ingredients | Heirloom apple & grape stem cells, coenzyme Q10, goji glycopeptides, aloe vera |
| Size | 0.6 fl oz |
| Fragrance-free | No |
Formulated with peptides, hyaluronic acid, niacinamide, and ectoin, this serum helps to “fill lines” and “boost moisture and volume,” according to Dr. Garshick. Four different sizes of hyaluronic acid penetrate the skin at different levels to plump and hydrate, while peptides visibly firm and lift the skin—plus, niacinamide and ectoin helps reduce redness and strengthen the skin barrier. It’s also formulated to provide both immediate and long-term results.
What a reviewer says: “I’m impressed with how lightweight this moisturizing lotion is. It goes on smoothly and gets absorbed by the skin in no time,” one customer shared. “It’s great for sensitive skin and a great choice for moisturizing my face. Since I’ve been using it regularly for a few weeks now, I’ve noticed a remarkable difference in how smooth and healthy my skin looks and feels. I couldn’t be happier with the results.”
Features at a Glance
| Key ingredients | Hyaluronic acid, peptides, ectoin, niacinamide |
| Size | 1 fl oz |
| Fragrance-free | Yes |
Dr. Garshick recommends this advanced, targeted serum for its ability to “reduce the appearance of expression lines” with a patent-pending blend of peptides as well as “plump the skin” and reduce dryness with hyaluronic acid. “It can be used twice daily and should be massaged into any area of fine lines and wrinkles,” she adds. It’s formulated to visibly reduce expression lines, fine lines, wrinkles, and pore size with a blend of peptides and collagen-supporting ingredients, while also supporting a balanced microbiome for healthier skin.
What a reviewer says: “I am 58 years old and stopped using Botox five years ago. Since stopping, I have had a lot of deep wrinkles around my eyes and forehead,” shared one shopper. “I was reluctant to invest a lot of money on a product like this, but I am seeing some dramatic results. Yes, the wrinkles are still there, but the creases are much smaller, finer, and I think are suitable for a woman my age.”
Features at a Glance
| Key ingredients | Peptides, hyaluronic acid, arnica, glycerin |
| Size | 0.25 oz |
| Fragrance-free | Yes |
Do wrinkle fillers really work?
While at-home (topical) products can certainly do wonders in improving the appearance of wrinkles, “the effect is generally considered temporary,” Dr. Garshick explains. However, certain ingredients that have been shown to boost collagen production (like retinol and peptides) may be beneficial in improving the appearance of wrinkles long-term, she adds.
“When used regularly, topical wrinkle serums can be effective at improving wrinkles and preventing new ones,” Dr. Mraz agrees. “However, they can be most effective when paired with treatments such as lasers and injectable neuromodulators.” In other words: Don’t expect your at-home creams and serums to have the same level of effectiveness as in-office treatments.
How long do wrinkle fillers last?
Generally, the effects of topical wrinkle fillers are temporary. According to Dr. Garshick, wrinkle fillers with ingredients like silicones or film-forming agents typically provide temporary wrinkle-smoothing benefits that only last several hours or until you wash your face. Formulas that “contain active ingredients like peptides, retinoids, or growth factors can lead to more lasting improvement, but these results develop gradually with consistent use over weeks to months,” she explains.
All in all: “It’s important to set realistic expectations as topical wrinkle fillers can improve the appearance of fine lines, but do not necessarily replace in-office treatments, especially for deeper wrinkles,” Dr. Garshick says.
What is the best way to apply wrinkle filler?
The best way to apply a wrinkle filler generally depends on the specific formulation of the product, says Dr. Garshick. “For serums it is best to apply to the skin after cleansing and prior to moisturizing, while for cream-based formulations it may be best to apply as a last step in an evening routine or just prior to sunscreen in a morning routine,” she explains. “For best results, it should be used daily and it is recommended to follow package instructions, as some may be intended for the lines specifically while others may be applied to the whole face.”
How to choose the best wrinkle fillers
Experts recommend looking for the following ingredients in at-home wrinkle fillers:
✔️ Hyaluronic acid. This ultra-hydrating ingredient helps “to draw moisture in and works to plump the skin,” Dr. Garshick says.
✔️ Retinol. Retinol has been proven to prevent and address visible signs of aging, including fine lines and wrinkles, for its ability to regulate skin cell turnover and boost collagen production.
✔️ Bakuchiol. For those who are sensitive to retinol, bakuchiol is a great plant-based alternative that can also improve the appearance of fines lines and wrinkles—but often with less irritation, according to Dr. Garshick.
✔️ Peptides. Like retinol, peptides help boost collagen. In doing so, peptide serums and creams can help plump the skin and reduce the appearance of fine lines and wrinkles.
✔️ Niacinamide. A form of vitamin B3, this ingredient “helps strengthen the skin barrier, improve tone and texture, and reduce inflammation, making skin appear smoother and more even,” explains Dr. Garshick.
✔️ Antioxidants. “These protect against free radical damage from UV exposure and pollution, which contribute to premature aging,” Dr. Garshick says. “Vitamin C in particular can help brighten the skin and support collagen synthesis.”
✔️ Growth factors. Growth factors are proteins that help to naturally repair the skin. These help support collagen production and skin repair to improve the appearance of fine lines over time, according to experts.
✔️ Silicones and light-diffusing particles. “While not treating wrinkles long term, these ingredients can provide an immediate blurring and smoothing effect, which is helpful for instant cosmetic improvement,” explains Dr. Garshick.
How we chose the best wrinkle fillers
We spoke with Joshua Zeichner, M.D., a board-certified dermatologist and director of cosmetic and clinical research in dermatology at the Mount Sinai Medical Center in NYC; Deanne Mraz, M.D., F.A.A.D., board-certified dermatologist, President and Co-Founder of Modern Dermatology of Connecticut; and Marisa Garshick, M.D., a board-certified dermatologist at MDCS Dermatology in NYC. We also pored through countless product reviews, ratings, and specs to select the best wrinkle fillers available.
Why trust us
For more than 70 years, Prevention has been a leading provider of trustworthy health information, empowering readers with practical strategies to improve their physical, mental, and emotional well-being. Our editors interview medical experts to help guide our health-focused product selections. Additionally, Prevention also examines hundreds of reviews—and often conducts personal testing done by our staff—to help you make informed decisions.
Shannen Zitz is the Associate Style & Commerce Editor at Women’s Health, where she covers all-things sneakers and activewear. Previously, she was an assistant editor at Prevention. Shannen graduated from the State University of New York at Cortland with a bachelor’s degree in English. If she’s not reading or writing, you can probably find her frequenting the skincare and makeup forums on Reddit or hogging the squat rack at the gym.
Charlotte Lewis Finigan is the Senior Commerce Editor at Prevention. After a decade of working in Hollywood writers’ rooms and contributing pop culture writing to ETOnline, Bustle, TVGuide, and CBS, she underwent bariatric surgery and changed her focus to health and wellness. Previously, Charlotte was the Sexual Health & Wellness Writer for Refinery 29. There, she wrote and edited shopping content about new wellness trends, beauty launches, and sex-positive products. She currently lives in Brooklyn with her girlfriend—and the love of her life, her senior dog, Rory. All three can typically be found perusing the Fort Green farmer’s market for fresh produce or curling up on the couch to watch Survivor.
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