“Excessive blood clotting can be caused by a variety of factors, including genetics, medication and certain situations and diseases,” says Dr. Reynolds. “We typically group those factors into two categories: Acquired and genetic.”

“Acquired means that the blood clotting was triggered by another disease or condition,” Dr. Reynolds explains. “Examples are smoking, obesity, pregnancy, use of birth control pills or hormone replacement therapy, diabetes, cancer, prolonged bed rest, or long car and plane trips.” Other common acquired risk factors, according to The National Library of Medicine, include COVID-19, diabetes, serious injuries, atrial fibrillation, and atherosclerosis.

Blood clots that result from genetic risk factors are rarer and usually the result of genetic defects, per Dr. Reynolds. However, family history may also play a role.

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