“Botox in a bottle” has become the buzzy nickname for topical wrinkle fillers and powerful anti-aging serums that promise youthful-looking skin, plus it’s one of the best alternatives to in-office treatments—no needles, numbing cream, or appointment required. But the real question is, just how well do these powerhouse skincare products stack up against the tried and true in-office treatments? We tapped a few dermatologists to learn more.
Botox (a.k.a. Botulinum toxin type A), known as a neuromodulator, “is essentially a muscle relaxant, and it was through the treatment of muscle spasms that we discovered that by relaxing the muscles responsible for a lot of the dynamic lines that you see in people’s faces, it was softening wrinkles as well,” explains Karan Lal, D.O., M.S., F.A.A.D., double board-certified dermatologist with Affiliated Dermatology in Scottsdale, AZ.
Meet the experts: Karan Lal, D.O., M.S., F.A.A.D., double board-certified dermatologist with Affiliated Dermatology in Scottsdale, AZ; Laura Scott, M.D., board-certified dermatologist; Dendy Engelman, M.D., board-certified dermatologic surgeon at Medical Dermatology & Cosmetic Surgery in New York City.
Now, there are plenty of anti-aging serums, facial moisturizers, and eye creams, that aim to emulate the results of an in-office, injectable treatment (hence the name “Botox in a bottle”). “While there is nothing in the world that can truly replace Botox,” says Dendy Engelman, M.D., board-certified dermatologic surgeon at Medical Dermatology & Cosmetic Surgery in NYC, “these products feature ingredients that contribute to overall skin health and can reduce the appearance of fine lines and wrinkles.”
Ahead, find out exactly which Botox in a bottle skincare products dermatologists say have earned the name. Each pick is jam-packed with effective skincare ingredients that promote firmer, smoother, more youthful-looking skin.
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Shannen Zitz is the Associate Style & Commerce Editor at Women’s Health, where she covers all-things sneakers and activewear. Previously, she was an assistant editor at Prevention. Shannen graduated from the State University of New York at Cortland with a bachelor’s degree in English. If she’s not reading or writing, you can probably find her frequenting the skincare and makeup forums on Reddit or hogging the squat rack at the gym.
“,”jobTitle”:”Associate Style & Commerce Editor”,”image”:”https://hips.hearstapps.com/rover/profile_photos/75d89ec3-0683-4831-8915-edd0a0ac1db4_1705010672.jpg”}],”about”:{“@type”:”ItemList”,”numberOfItems”:17,”itemListElement”:[{“@type”:”ListItem”,”position”:1,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Argireline Solution 10%”,”description”:”“If I were to call anything ‘Botox in a bottle,’ it would be the Argireline serum from The Ordinary,” says Dr. Lal. “Argireline is a neuropeptide that works very similarly to Botox. It softens fine lines, reduces pore size, and gives the skin a nice taut and firm appearance.” It also comes recommended by board-certified dermatologist Laura Scott, M.D. for its simple formula and ability to “smooth out fine lines.”User review: “This is truly Botox in a bottle, if you use it consistently. I have definitely noticed a decrease in my forehead lines. Highly recommend,” wrote one Sephora shopper.”,”image”:”https://vader-prod.s3.amazonaws.com/1698761912-the-ordinary-argireline-solution-65410c951c836.jpg”,”brand”:{“@type”:”Brand”,”name”:”The Ordinary”},”review”:{“@type”:”Review”,”name”:”Argireline Solution 10%”,”image”:”https://vader-prod.s3.amazonaws.com/1698761912-the-ordinary-argireline-solution-65410c951c836.jpg”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”“If I were to call anything ‘Botox in a bottle,’ it would be the Argireline serum from The Ordinary,” says Dr. Lal. “Argireline is a neuropeptide that works very similarly to Botox. It softens fine lines, reduces pore size, and gives the skin a nice taut and firm appearance.” It also comes recommended by board-certified dermatologist Laura Scott, M.D. for its simple formula and ability to “smooth out fine lines.”User review: “This is truly Botox in a bottle, if you use it consistently. I have definitely noticed a decrease in my forehead lines. Highly recommend,” wrote one Sephora shopper.”,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Contains a powerful neurotransmitter peptide “},{“@type”:”ListItem”,”position”:”2″,”name”:”Addresses fine lines and wrinkles”},{“@type”:”ListItem”,”position”:”3″,”name”:”Potent formula”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Some reviewers found the formula too liquidy”}]}}}},{“@type”:”ListItem”,”position”:2,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Instant FIRMx Temporary Eye Tightener”,”description”:”If you’re looking for instant results, Dr. Lal recommends this cream that has earned high praise from all corners of the internet. It works differently than other “Botox in a bottle” products in that it forms a film on the skin thanks to the silicates in the formula, giving the skin a taut appearance and drastically softening lines, wrinkles, and texture, says Dr. Lal.User review: “The instant results are truly remarkable. Upon application, the Eye Tightener works its magic, visibly tightening and lifting the delicate skin around my eyes. Fine lines, wrinkles, and puffiness seem to vanish, leaving a smooth and revitalized appearance. It’s like having an instant facelift specifically tailored for the eyes,” wrote one Amazon shopper.”,”image”:”https://vader-prod.s3.amazonaws.com/1698432923-peter-thomas-roth-instant-firmx-temporary-eye-tightener-653c078387107.png”,”brand”:{“@type”:”Brand”,”name”:”Peter Thomas Roth”},”review”:{“@type”:”Review”,”name”:”Instant FIRMx Temporary Eye Tightener”,”image”:”https://vader-prod.s3.amazonaws.com/1698432923-peter-thomas-roth-instant-firmx-temporary-eye-tightener-653c078387107.png”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”If you’re looking for instant results, Dr. Lal recommends this cream that has earned high praise from all corners of the internet. It works differently than other “Botox in a bottle” products in that it forms a film on the skin thanks to the silicates in the formula, giving the skin a taut appearance and drastically softening lines, wrinkles, and texture, says Dr. Lal.User review: “The instant results are truly remarkable. Upon application, the Eye Tightener works its magic, visibly tightening and lifting the delicate skin around my eyes. Fine lines, wrinkles, and puffiness seem to vanish, leaving a smooth and revitalized appearance. It’s like having an instant facelift specifically tailored for the eyes,” wrote one Amazon shopper.”,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Addresses fine lines and wrinkles “},{“@type”:”ListItem”,”position”:”2″,”name”:”Formulated with peptides to smooth skin over time “},{“@type”:”ListItem”,”position”:”3″,”name”:”Wears well under makeup”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Results are only temporary”}]}}}},{“@type”:”ListItem”,”position”:3,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Age Renew Retinol Overnight Body and Face Lotion”,”description”:”Retinol benefits abound, especially for those looking to reduce visible signs of aging. This affordable face and body lotion contains not only retinol but firming peptides and hydrating ingredients as well. Dr. Scott says this product is a “great option” and can usually be found in drugstores. “It’s formulated with retinol, peptides, urea, and niacinamide to smooth skin,” she explains. Plus, “93% of users had visibly smoother skin in three days,” she says.User review: “Love this stuff! I use it every day on my face and neck and after about a month, the deepest wrinkles on my face and neck have noticeably diminished! I honestly did not think I would see such a difference! Also, it doesn’t burn my face like some of the other retinol brands I have used,” wrote one Amazon shopper.”,”image”:”https://vader-prod.s3.amazonaws.com/1690217283-71oVA1y3BHL.jpg”,”brand”:{“@type”:”Brand”,”name”:”Gold Bond”},”review”:{“@type”:”Review”,”name”:”Age Renew Retinol Overnight Body and Face Lotion”,”image”:”https://vader-prod.s3.amazonaws.com/1690217283-71oVA1y3BHL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”Retinol benefits abound, especially for those looking to reduce visible signs of aging. This affordable face and body lotion contains not only retinol but firming peptides and hydrating ingredients as well. Dr. Scott says this product is a “great option” and can usually be found in drugstores. “It’s formulated with retinol, peptides, urea, and niacinamide to smooth skin,” she explains. Plus, “93% of users had visibly smoother skin in three days,” she says.User review: “Love this stuff! I use it every day on my face and neck and after about a month, the deepest wrinkles on my face and neck have noticeably diminished! I honestly did not think I would see such a difference! Also, it doesn’t burn my face like some of the other retinol brands I have used,” wrote one Amazon shopper.”,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Addresses fine lines and wrinkles “},{“@type”:”ListItem”,”position”:”2″,”name”:”Hydrating formula”},{“@type”:”ListItem”,”position”:”3″,”name”:”Affordable”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Some reviewers found the formula too heavy for face”}]}}}},{“@type”:”ListItem”,”position”:4,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Targeted Wrinkle Corrector”,”description”:”Reviewers can’t stop raving about how well this wrinkle corrector works. When applied as directed, it instantly fills and blurs deep-set lines and creases. Dr. Daniel Sugai, M.D., board-certified dermatologist at North Pacific Dermatology, in Washington State, recommends using the wrinkle corrector specifically for static wrinkles (those that remain visible even when your face is at rest). The formula features powerhouse ingredients like acetyl-hexapeptide-8 to help improve elasticity and squalane to prevent moisture loss, which can lead to future wrinkles.User review:“After using the corrector for a few weeks, I started seeing noticeable improvements in the appearance of my wrinkles. The texture of the wrinkle corrector is lightweight and velvety, making it a pleasure to apply. It glides on smoothly and absorbs quickly into the skin without leaving any greasy or sticky residue behind. I appreciated that it didn’t interfere with the application of my makeup and worked well as a base under my foundation.””,”image”:”https://vader-prod.s3.amazonaws.com/1765571638-s2533180-main-zoom.jpg”,”brand”:{“@type”:”Brand”,”name”:”Murad”},”review”:{“@type”:”Review”,”name”:”Targeted Wrinkle Corrector”,”image”:”https://vader-prod.s3.amazonaws.com/1765571638-s2533180-main-zoom.jpg”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”Reviewers can’t stop raving about how well this wrinkle corrector works. When applied as directed, it instantly fills and blurs deep-set lines and creases. Dr. Daniel Sugai, M.D., board-certified dermatologist at North Pacific Dermatology, in Washington State, recommends using the wrinkle corrector specifically for static wrinkles (those that remain visible even when your face is at rest). The formula features powerhouse ingredients like acetyl-hexapeptide-8 to help improve elasticity and squalane to prevent moisture loss, which can lead to future wrinkles.User review:“After using the corrector for a few weeks, I started seeing noticeable improvements in the appearance of my wrinkles. The texture of the wrinkle corrector is lightweight and velvety, making it a pleasure to apply. It glides on smoothly and absorbs quickly into the skin without leaving any greasy or sticky residue behind. I appreciated that it didn’t interfere with the application of my makeup and worked well as a base under my foundation.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Visbly plumps skin”},{“@type”:”ListItem”,”position”:”2″,”name”:”Prevents formation of future wrinkles”},{“@type”:”ListItem”,”position”:”3″,”name”:”Boosts elasticity”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Some reviewers say it doesn’t layer well with makeup”}]}}}},{“@type”:”ListItem”,”position”:5,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”P-TIOX Anti-Wrinkle Peptide Serum”,”description”:”This trending product from SkinCeuticals “has been shown to visibly reduce nine types of expression lines and give that ‘glass skin’ appearance in one week,” says Dr. Lal. He adds that the results are powered by an effective peptide complex, a gentle exfoliant (polyhydroxy acid), and niacinamide which not only aid with wrinkle reduction but overall skin health and hydration as well.User review: “I don’t use neuromodulators, but I have noticed a difference in my skin texture and appearance since adding this to my routine along with SkinCeuticals CE Ferulic morning and night. My small forehead lines and crow’s feet are less noticeable and my skin looks smoother overall,” wrote one shopper on the Dermstore website.”,”image”:”https://vader-prod.s3.amazonaws.com/1731945057-skinceuticals-ptiox-673b620922988.jpg”,”brand”:{“@type”:”Brand”,”name”:”SkinCeuticals”},”review”:{“@type”:”Review”,”name”:”P-TIOX Anti-Wrinkle Peptide Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1731945057-skinceuticals-ptiox-673b620922988.jpg”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”This trending product from SkinCeuticals “has been shown to visibly reduce nine types of expression lines and give that ‘glass skin’ appearance in one week,” says Dr. Lal. He adds that the results are powered by an effective peptide complex, a gentle exfoliant (polyhydroxy acid), and niacinamide which not only aid with wrinkle reduction but overall skin health and hydration as well.User review: “I don’t use neuromodulators, but I have noticed a difference in my skin texture and appearance since adding this to my routine along with SkinCeuticals CE Ferulic morning and night. My small forehead lines and crow’s feet are less noticeable and my skin looks smoother overall,” wrote one shopper on the Dermstore website.”,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Addresses fine lines and wrinkles”},{“@type”:”ListItem”,”position”:”2″,”name”:” Gently exfoliates “},{“@type”:”ListItem”,”position”:”3″,”name”:”Contains hydrating ingredients”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey”}]}}}},{“@type”:”ListItem”,”position”:6,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Lift-Tox Night Cream”,”description”:”“The biggest ingredients to look for are retinol and peptides (that help stimulate the skin to produce collagen), Dr. Scott explains. This night cream is packed with a potent blend of Collaxyl, Argireline, Matrixyl 3000, lifting peptides, and antioxidants that all work to repair, lift, and contour the skin while you sleep. The brand’s clinical testing even shows improved skin firmness after just eight hours of sleep.User review: “If you have dry skin, this is exactly the type of face cream you need. I had a spot on my face that peeled and was slightly red after using tretinoin. This did not burn or irritate the areas where my skin barrier was broken and helped to heal it. But what I’m most impressed with is the complete lack of scent. Many thick creams like this have an “old lady” smell or are highly perfumed. This truly has zero scent to me, and I love that.””,”image”:”https://vader-prod.s3.amazonaws.com/1765572535-61DvSg8vlLL.jpg”,”brand”:{“@type”:”Brand”,”name”:”Nakery”},”review”:{“@type”:”Review”,”name”:”Lift-Tox Night Cream”,”image”:”https://vader-prod.s3.amazonaws.com/1765572535-61DvSg8vlLL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”“The biggest ingredients to look for are retinol and peptides (that help stimulate the skin to produce collagen), Dr. Scott explains. This night cream is packed with a potent blend of Collaxyl, Argireline, Matrixyl 3000, lifting peptides, and antioxidants that all work to repair, lift, and contour the skin while you sleep. The brand’s clinical testing even shows improved skin firmness after just eight hours of sleep.User review: “If you have dry skin, this is exactly the type of face cream you need. I had a spot on my face that peeled and was slightly red after using tretinoin. This did not burn or irritate the areas where my skin barrier was broken and helped to heal it. But what I’m most impressed with is the complete lack of scent. Many thick creams like this have an “old lady” smell or are highly perfumed. This truly has zero scent to me, and I love that.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Improves sagging skin overnight”},{“@type”:”ListItem”,”position”:”2″,”name”:”Reduces the appearance of lines and crepey texture”},{“@type”:”ListItem”,”position”:”3″,”name”:”Tightens and reshapes face”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Some reviewers say it takes awhile to see results”}]}}}},{“@type”:”ListItem”,”position”:7,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Crystal Retinal Ceramide Eye 6″,”description”:”If you’re looking to hold off or avoid Botox around the eyes, try this Vitamin A-enriched eye cream. Dr. Englman says this formula “is great for targeting the eye area to reduce the appearance of crow’s feet, wrinkles, crepiness, and puffiness.” It contains retinaldehyde, a more gentle form of retinol, as well as ceramides and hyaluronic acid to smooth the skin with less risk of irritation.User review: “Love this product, had zero irritation which was a huge surprise as I have sensitive eyes. My eyes went from crepey (I’m 58) to smooth which I never thought would happen! Will definitely be a permanent addition to my skincare routine.””,”image”:”https://vader-prod.s3.amazonaws.com/1698432701-51i26QVCagL.jpg”,”brand”:{“@type”:”Brand”,”name”:”Medik8″},”review”:{“@type”:”Review”,”name”:”Crystal Retinal Ceramide Eye 6″,”image”:”https://vader-prod.s3.amazonaws.com/1698432701-51i26QVCagL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”If you’re looking to hold off or avoid Botox around the eyes, try this Vitamin A-enriched eye cream. Dr. Englman says this formula “is great for targeting the eye area to reduce the appearance of crow’s feet, wrinkles, crepiness, and puffiness.” It contains retinaldehyde, a more gentle form of retinol, as well as ceramides and hyaluronic acid to smooth the skin with less risk of irritation.User review: “Love this product, had zero irritation which was a huge surprise as I have sensitive eyes. My eyes went from crepey (I’m 58) to smooth which I never thought would happen! Will definitely be a permanent addition to my skincare routine.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Addresses crow’s feet “},{“@type”:”ListItem”,”position”:”2″,”name”:”Hydrating formula “},{“@type”:”ListItem”,”position”:”3″,”name”:”Available in three strengths”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey”}]}}}},{“@type”:”ListItem”,”position”:8,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Replenishing Lip Filler”,”description”:”Lip filler treatments have been growing in popularity for years, thanks to a few of our favorite celebrities (hello, Dolly Parton) and influencers. But regular in-office treatments can get expensive, and keeping up with frequent appointments isn’t always easy. That’s where this natural lip filler comes in. It uses patented Tiered-Release Vesicle Delivery Technology to push hyaluronic acid and peptides deep into the skin, building volume and shine from within.User review: “So I have been using the Ourself lip filler for a few years. I loved both the old formula and the new formula. I do get lit filler once a year, but I find that this helps so much. If I stop using it, I definitely notice a difference. I will be using these forever. I will admit it is a bit pricey, but it is definitely worth it, though.””,”image”:”https://vader-prod.s3.amazonaws.com/1765573029-3-f8144833-5f0f-467a-81de-533b82ac8c7e-876×776-crop-center-693c8187280ba.png”,”brand”:{“@type”:”Brand”,”name”:”Ourself”},”review”:{“@type”:”Review”,”name”:”Replenishing Lip Filler”,”image”:”https://vader-prod.s3.amazonaws.com/1765573029-3-f8144833-5f0f-467a-81de-533b82ac8c7e-876×776-crop-center-693c8187280ba.png”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”Lip filler treatments have been growing in popularity for years, thanks to a few of our favorite celebrities (hello, Dolly Parton) and influencers. But regular in-office treatments can get expensive, and keeping up with frequent appointments isn’t always easy. That’s where this natural lip filler comes in. It uses patented Tiered-Release Vesicle Delivery Technology to push hyaluronic acid and peptides deep into the skin, building volume and shine from within.User review: “So I have been using the Ourself lip filler for a few years. I loved both the old formula and the new formula. I do get lit filler once a year, but I find that this helps so much. If I stop using it, I definitely notice a difference. I will be using these forever. I will admit it is a bit pricey, but it is definitely worth it, though.””,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Improves volume”},{“@type”:”ListItem”,”position”:”2″,”name”:”Smooths lip lines”},{“@type”:”ListItem”,”position”:”3″,”name”:”Hydrating”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Only available at Ourself”}]}}}},{“@type”:”ListItem”,”position”:9,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Revox Line Relaxer”,”description”:”Dr. Lal recommends this serum from Revision Skincare for its ability to not only help soften lines around the eyes, but to help maintain the results of in-office Botox should you choose to go that route. It’s formulated with a variety of peptides and hydrating hyaluronic acid, making it a standout product for smoothing the skin with or without injectables. User review: “I am 58 years old and stopped using Botox five years ago. Since stopping, I have had a lot of deep wrinkles around my eyes and forehead. I was reluctant to invest a lot of money on a product like this, but I am seeing some dramatic results. Yes, the wrinkles are still there, but the creases are much smaller, finer, and I think are suitable for a woman my age,” wrote one Amazon shopper.”,”image”:”https://vader-prod.s3.amazonaws.com/1698433273-41ySP9djaL.jpg”,”brand”:{“@type”:”Brand”,”name”:”Revision Skincare”},”review”:{“@type”:”Review”,”name”:”Revox Line Relaxer”,”image”:”https://vader-prod.s3.amazonaws.com/1698433273-41ySP9djaL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”Dr. Lal recommends this serum from Revision Skincare for its ability to not only help soften lines around the eyes, but to help maintain the results of in-office Botox should you choose to go that route. It’s formulated with a variety of peptides and hydrating hyaluronic acid, making it a standout product for smoothing the skin with or without injectables. User review: “I am 58 years old and stopped using Botox five years ago. Since stopping, I have had a lot of deep wrinkles around my eyes and forehead. I was reluctant to invest a lot of money on a product like this, but I am seeing some dramatic results. Yes, the wrinkles are still there, but the creases are much smaller, finer, and I think are suitable for a woman my age,” wrote one Amazon shopper.”,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Addresses fine lines and wrinkles “},{“@type”:”ListItem”,”position”:”2″,”name”:”Cooling applicator “},{“@type”:”ListItem”,”position”:”3″,”name”:”Formulated to complement in-office treatments”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey”}]}}}},{“@type”:”ListItem”,”position”:10,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”ELASTIderm Lift Up & Sculpt Facial Moisturizer”,”description”:”Practicing a good skincare routine daily can make a difference in signs of aging, and using an effective facial moisturizer like this one should be at the top of your list. It’s formulated with powerful peptides that support skin elasticity and promote a lifted, youthful look. Its lightweight yet rich texture absorbs easily, providing hydration and helping to improve overall skin tone and texture. User review: “I started using this sculpting cream three months ago and my face and neck feel tight and firm. I can see the difference in my skin; it has restored elasticity to my face and neck. There is no smell, the cream is completely non-greasy, and it just melts into your skin, leaving it firm and supple. Yes, it is pricey, but it’s worth every penny. A little bit goes a long way!” “,”image”:”https://vader-prod.s3.amazonaws.com/1765574119-51BuDe3XKL.jpg”,”brand”:{“@type”:”Brand”,”name”:”Obagi Medical”},”review”:{“@type”:”Review”,”name”:”ELASTIderm Lift Up & Sculpt Facial Moisturizer”,”image”:”https://vader-prod.s3.amazonaws.com/1765574119-51BuDe3XKL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”Practicing a good skincare routine daily can make a difference in signs of aging, and using an effective facial moisturizer like this one should be at the top of your list. It’s formulated with powerful peptides that support skin elasticity and promote a lifted, youthful look. Its lightweight yet rich texture absorbs easily, providing hydration and helping to improve overall skin tone and texture. User review: “I started using this sculpting cream three months ago and my face and neck feel tight and firm. I can see the difference in my skin; it has restored elasticity to my face and neck. There is no smell, the cream is completely non-greasy, and it just melts into your skin, leaving it firm and supple. Yes, it is pricey, but it’s worth every penny. A little bit goes a long way!” “,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Lifts and contours skin”},{“@type”:”ListItem”,”position”:”2″,”name”:”Hydrating”},{“@type”:”ListItem”,”position”:”3″,”name”:”Plumping”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Some reviewers say the fragrance is overpowering”}]}}}},{“@type”:”ListItem”,”position”:11,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”DermInfusions Fill + Repair Serum”,”description”:”Formulated with bakuchiol, peptides, hyaluronic acid, and alpha hydroxy acids (AHAs), this serum helps to “smooth lines and plump skin,” says Dr. Scott. The serum is formulated to provide immediate and long-term results with a variety of ingredients designed to deeply hydrate the skin while boosting collagen production with continued use. User review: “I’m impressed with how lightweight this moisturizing lotion is. It goes on smoothly and gets absorbed by the skin in no time. It’s great for sensitive skin and a great choice for moisturizing my face. Since I’ve been using it regularly for a few weeks now, I’ve noticed a remarkable difference in how smooth and healthy my skin looks and feels. I couldn’t be happier with the results,” wrote one Amazon shopper.”,”image”:”https://vader-prod.s3.amazonaws.com/1698433702-dr-dennis-gross-derminfusions-fill-repair-serum-653c0a9464f4c.png”,”brand”:{“@type”:”Brand”,”name”:”Dr. Dennis Gross”},”review”:{“@type”:”Review”,”name”:”DermInfusions Fill + Repair Serum”,”image”:”https://vader-prod.s3.amazonaws.com/1698433702-dr-dennis-gross-derminfusions-fill-repair-serum-653c0a9464f4c.png”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”Formulated with bakuchiol, peptides, hyaluronic acid, and alpha hydroxy acids (AHAs), this serum helps to “smooth lines and plump skin,” says Dr. Scott. The serum is formulated to provide immediate and long-term results with a variety of ingredients designed to deeply hydrate the skin while boosting collagen production with continued use. User review: “I’m impressed with how lightweight this moisturizing lotion is. It goes on smoothly and gets absorbed by the skin in no time. It’s great for sensitive skin and a great choice for moisturizing my face. Since I’ve been using it regularly for a few weeks now, I’ve noticed a remarkable difference in how smooth and healthy my skin looks and feels. I couldn’t be happier with the results,” wrote one Amazon shopper.”,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Instantly hydrates and plumps skin “},{“@type”:”ListItem”,”position”:”2″,”name”:”Addresses fine lines and wrinkles “},{“@type”:”ListItem”,”position”:”3″,”name”:”Potent formula”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Some reviewers dislike the scent “}]}}}},{“@type”:”ListItem”,”position”:12,”item”:{“@context”:”https://schema.org/”,”@type”:”Product”,”name”:”Pro-Max Age Renewal”,”description”:”Dr. Lal praises this product from PCA Skin for its anti-aging properties. “This serum has been shown to smooth visible lines and coarse wrinkles by 40% and to clinically lift and firm the appearance of skin by 60%,” he explains. “It has micro growth factors which help stimulate collagen along with skin firming biopolymers which actually provide an instant skin-firming and reduction effect on wrinkles.”User review: “This has become one of my holy grail products. I am now on my third bottle and cannot live without it,” wrote one Dermstore shopper. “My skin type is dry and since using this I get so many compliments on how glowy and glass-like my skin is. I will continue to repurchase.” “,”image”:”https://vader-prod.s3.amazonaws.com/1692890567-518ptDY3POL.jpg”,”brand”:{“@type”:”Brand”,”name”:”PCA SKIN”},”review”:{“@type”:”Review”,”name”:”Pro-Max Age Renewal”,”image”:”https://vader-prod.s3.amazonaws.com/1692890567-518ptDY3POL.jpg”,”author”:[{“@type”:”Person”,”name”:”Shauna Beni”},{“@type”:”Person”,”name”:”Shannen Zitz”}],”reviewBody”:”Dr. Lal praises this product from PCA Skin for its anti-aging properties. “This serum has been shown to smooth visible lines and coarse wrinkles by 40% and to clinically lift and firm the appearance of skin by 60%,” he explains. “It has micro growth factors which help stimulate collagen along with skin firming biopolymers which actually provide an instant skin-firming and reduction effect on wrinkles.”User review: “This has become one of my holy grail products. I am now on my third bottle and cannot live without it,” wrote one Dermstore shopper. “My skin type is dry and since using this I get so many compliments on how glowy and glass-like my skin is. I will continue to repurchase.” “,”positiveNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Helps smooth and firm the skin “},{“@type”:”ListItem”,”position”:”2″,”name”:”Stimulates collagen”},{“@type”:”ListItem”,”position”:”3″,”name”:”Formulated with peptides to address wrinkles over time”}]},”negativeNotes”:{“@type”:”ItemList”,”itemListElement”:[{“@type”:”ListItem”,”position”:”1″,”name”:”Pricey”}]}}}},{“@type”:”ListItem”,”position”:13,”name”:”How to choose the best Botox in a bottle product”,”url”:”https://www.prevention.com/beauty/skin-care/g69710768/botox-in-a-bottle-skincare-products/”,”description”:”✔️ Focus on ingredients. “The biggest ingredients to look for are humectants like hyaluronic acid and/or urea, for example (that help plump the skin by holding onto water),” Dr. Scott explains. Growth factors, which work similarly to peptides, are also worth looking for in a product, says Dr. Lal.✔️ Avoid irritants. A lot of “fancy” products (that often come with a high price tag) sneak in potentially irritating ingredients like fragrance. While some skin types can handle a bit of a scent or perfume in their skincare products, if you have a history of sensitive skin or get irritation from serums or creams, Dr. Lal says to scan your product labels and put down the scented products to avoid getting sidetracked from your skincare goals.✔️ Consider price. Luckily, there are many amazing and affordable products on the market, like the expert-recommended Argireline serum from The Ordinary or Avene Hyaluron ACTIV B3 Concentrated Plumping Serum. So don’t feel like you need to splurge on a product if it’s not in your budget. ✔️ Think about your goals. If you want long-term results that you’re willing to wait for, consider a formula that contains ingredients proven to reduce fine lines and smooth the skin. But, if you’re looking for a temporary fix, a product like the Temporary Face Tightener by Peter Thomas Roth might suit your needs better. “,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”},{“@type”:”ListItem”,”position”:14,”name”:”How does Botox in a bottle work?”,”url”:”https://www.prevention.com/beauty/skin-care/g69710768/botox-in-a-bottle-skincare-products/”,”description”:”“Botox-in-a-bottle products are those that mimic the effects of Botox in terms of helping to smooth out fine lines and help the skin look more plump and youthful,” explains Dr. Scott. The way that each product works to improve the appearance of the skin depends on its active ingredients. “,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”},{“@type”:”ListItem”,”position”:15,”name”:”How do the results of Botox in a bottle compare to regular Botox? “,”url”:”https://www.prevention.com/beauty/skin-care/g69710768/botox-in-a-bottle-skincare-products/”,”description”:”“Botox does a couple of things. It shrinks your pores, softens fine lines, and gives your skin a nice taut appearance. And Botox, for the most part, we’re injecting it into the muscle,” explains Dr. Lal. “The muscle is very deep in the skin, so nothing you put on your skin is going to penetrate that muscle. But there are a few products that provide great results, and temporarily may provide some of those effects.” These topical products, in many cases, provide similar, albeit less drastic, results. Additionally, traditional Botox tends to work more quickly than Botox in-a-bottle products, which take longer to provide the expected smoothing, and lifting results. Plus, these products need to be applied regularly.”,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”},{“@type”:”ListItem”,”position”:16,”name”:”How we chose the best Botox in a bottle products”,”url”:”https://www.prevention.com/beauty/skin-care/g69710768/botox-in-a-bottle-skincare-products/”,”description”:”We spoke with Karan Lal, D.O., M.S., F.A.A.D., double board-certified dermatologist with Affiliated Dermatology in Scottsdale, AZ; Laura Scott, M.D., board-certified dermatologist; and Dendy Engelman, M.D., board-certified dermatologic surgeon. We also conducted our own research and sifted through hundreds of online reviews to find the best Botox in-a-bottle products available.”,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”},{“@type”:”ListItem”,”position”:17,”name”:”Why trust us “,”url”:”https://www.prevention.com/beauty/skin-care/g69710768/botox-in-a-bottle-skincare-products/”,”description”:”For more than 70 years, Prevention has been a leading provider of trustworthy health information, empowering readers with practical strategies to improve their physical, mental, and emotional well-being. Our editors interview medical experts to help guide our health-focused product selections. Additionally, Prevention also examines hundreds of reviews—and often conducts personal testing done by our staff—to help you make informed decisions.”,”image”:”https://hips.hearstapps.com/hmg-prod/images/prevention-line-break-1-1649871064.jpg”}]}}]
Reviewers can’t stop raving about how well this wrinkle corrector works. When applied as directed, it instantly fills and blurs deep-set lines and creases. Dr. Daniel Sugai, M.D., board-certified dermatologist at North Pacific Dermatology, in Washington State, recommends using the wrinkle corrector specifically for static wrinkles (those that remain visible even when your face is at rest). The formula features powerhouse ingredients like acetyl-hexapeptide-8 to help improve elasticity and squalane to prevent moisture loss, which can lead to future wrinkles.
User review:“After using the corrector for a few weeks, I started seeing noticeable improvements in the appearance of my wrinkles. The texture of the wrinkle corrector is lightweight and velvety, making it a pleasure to apply. It glides on smoothly and absorbs quickly into the skin without leaving any greasy or sticky residue behind. I appreciated that it didn’t interfere with the application of my makeup and worked well as a base under my foundation.”
Features at a Glance
| Key ingredients | Acetyl hexapeptide-8, Bioavailable hyaluronic acid, squalane |
| Benefits, per brand | Smoothing, firming, hydrating |
| Size | 0.5 fl oz |
“The biggest ingredients to look for are retinol and peptides (that help stimulate the skin to produce collagen), Dr. Scott explains. This night cream is packed with a potent blend of Collaxyl, Argireline, Matrixyl 3000, lifting peptides, and antioxidants that all work to repair, lift, and contour the skin while you sleep. The brand’s clinical testing even shows improved skin firmness after just eight hours of sleep.
User review: “If you have dry skin, this is exactly the type of face cream you need. I had a spot on my face that peeled and was slightly red after using tretinoin. This did not burn or irritate the areas where my skin barrier was broken and helped to heal it. But what I’m most impressed with is the complete lack of scent. Many thick creams like this have an “old lady” smell or are highly perfumed. This truly has zero scent to me, and I love that.”
Features at a Glance
| Key ingredients | Dolcevia, feminage, phytogen, collaxyl |
| Benefits, per brand | Lifts sagging skin, reduces fine lines, Infused with antioxidants |
| Size | 2 fl oz |
Lip filler treatments have been growing in popularity for years, thanks to a few of our favorite celebrities (hello, Dolly Parton) and influencers. But regular in-office treatments can get expensive, and keeping up with frequent appointments isn’t always easy. That’s where this natural lip filler comes in. It uses patented Tiered-Release Vesicle Delivery Technology to push hyaluronic acid and peptides deep into the skin, building volume and shine from within.
User review: “So I have been using the Ourself lip filler for a few years. I loved both the old formula and the new formula. I do get lit filler once a year, but I find that this helps so much. If I stop using it, I definitely notice a difference. I will be using these forever. I will admit it is a bit pricey, but it is definitely worth it, though.”
Features at a Glance
| Key ingredients | Hyaluronic acid complex, tiered-release vesicle, peptides |
| Benefits, per brand | Hydrating, volumizing, enhances shine |
| Size | 1.7 ml |
Practicing a good skincare routine daily can make a difference in signs of aging, and using an effective facial moisturizer like this one should be at the top of your list. It’s formulated with powerful peptides that support skin elasticity and promote a lifted, youthful look. Its lightweight yet rich texture absorbs easily, providing hydration and helping to improve overall skin tone and texture.
User review: “I started using this sculpting cream three months ago and my face and neck feel tight and firm. I can see the difference in my skin; it has restored elasticity to my face and neck. There is no smell, the cream is completely non-greasy, and it just melts into your skin, leaving it firm and supple. Yes, it is pricey, but it’s worth every penny. A little bit goes a long way!”
Features at a Glance
| Key ingredients | Bi-Mineral contour complex, Polyglutamic acid |
| Benefits, per brand | Replumps wrinkles, smooths crepiness |
| Size | 1.7 fl oz |
How to choose the best Botox in a bottle product
✔️ Focus on ingredients. “The biggest ingredients to look for are humectants like hyaluronic acid and/or urea, for example (that help plump the skin by holding onto water),” Dr. Scott explains. Growth factors, which work similarly to peptides, are also worth looking for in a product, says Dr. Lal.
✔️ Avoid irritants. A lot of “fancy” products (that often come with a high price tag) sneak in potentially irritating ingredients like fragrance. While some skin types can handle a bit of a scent or perfume in their skincare products, if you have a history of sensitive skin or get irritation from serums or creams, Dr. Lal says to scan your product labels and put down the scented products to avoid getting sidetracked from your skincare goals.
✔️ Consider price. Luckily, there are many amazing and affordable products on the market, like the expert-recommended Argireline serum from The Ordinary or Avene Hyaluron ACTIV B3 Concentrated Plumping Serum. So don’t feel like you need to splurge on a product if it’s not in your budget.
✔️ Think about your goals. If you want long-term results that you’re willing to wait for, consider a formula that contains ingredients proven to reduce fine lines and smooth the skin. But, if you’re looking for a temporary fix, a product like the Temporary Face Tightener by Peter Thomas Roth might suit your needs better.
How does Botox in a bottle work?
“Botox-in-a-bottle products are those that mimic the effects of Botox in terms of helping to smooth out fine lines and help the skin look more plump and youthful,” explains Dr. Scott. The way that each product works to improve the appearance of the skin depends on its active ingredients.
How do the results of Botox in a bottle compare to regular Botox?
“Botox does a couple of things. It shrinks your pores, softens fine lines, and gives your skin a nice taut appearance. And Botox, for the most part, we’re injecting it into the muscle,” explains Dr. Lal. “The muscle is very deep in the skin, so nothing you put on your skin is going to penetrate that muscle. But there are a few products that provide great results, and temporarily may provide some of those effects.”
These topical products, in many cases, provide similar, albeit less drastic, results. Additionally, traditional Botox tends to work more quickly than Botox in-a-bottle products, which take longer to provide the expected smoothing, and lifting results. Plus, these products need to be applied regularly.
How we chose the best Botox in a bottle products
Why trust us
For more than 70 years, Prevention has been a leading provider of trustworthy health information, empowering readers with practical strategies to improve their physical, mental, and emotional well-being. Our editors interview medical experts to help guide our health-focused product selections. Additionally, Prevention also examines hundreds of reviews—and often conducts personal testing done by our staff—to help you make informed decisions.
Shauna Beni is the Associate Commerce Editor at Prevention. An NYC native and beauty product lover, Shauna has written for Beauty Magazine, Condé Nast Traveler, and ABC News. She enjoys testing out new beauty products, watching makeup tutorials on Youtube, and binge-watching her favorite shows on Netflix. When she’s not writing, you can find her taking Zumba classes at Crunch, trying out natural curly hairstyles, and giving her friends advice on what makeup and haircare products they should buy. Follow her on Instagram @Beni127.
Shannen Zitz is the Associate Style & Commerce Editor at Women’s Health, where she covers all-things sneakers and activewear. Previously, she was an assistant editor at Prevention. Shannen graduated from the State University of New York at Cortland with a bachelor’s degree in English. If she’s not reading or writing, you can probably find her frequenting the skincare and makeup forums on Reddit or hogging the squat rack at the gym.
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