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Home » 6 Skin-Care Ingredient Combinations That Don’t Mix
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6 Skin-Care Ingredient Combinations That Don’t Mix

News RoomBy News RoomAugust 29, 2025No Comments1 Min Read
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Vitamin A derivatives like retinol and retinoids — and alpha hydroxy acids (AHAs) like glycolic acid — are a dermatologist’s go-to for anti-aging. They speed skin cell turnover and increase collagen production for glowy, fine line–free skin. Using them together, however, does not have the same effect. Because they both exfoliate the outer layer of skin, “they possess potentially irritating side effects, especially in combination,” says Elizabeth Bahar Houshmand, MD, a double-board-certified dermatologist in Dallas.

When skin shows signs of irritation (think: red, stingy, flaking, and peeling), you’re less likely to stick to the regimen. You don’t have to choose one or the other. She advises patients to use these topicals on alternate days (AHA on Monday, retinoid on Tuesday, and so on).

One exception? Products that have been specifically tested through clinical trials that combine retinoids and AHA, says Deirdre Hooper, MD, a board-certified dermatologist at Audubon Dermatology in New Orleans. One such is AlphaRet by Skinbetter Science. A study found that this combination retinoid cream performed as well as a prescription retinoid product in diminishing the signs of aging with fewer side effects like redness.

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