Biotinidase deficiency is a rare genetic condition in which the body is unable to recycle biotin for use. It can cause seizures, weak muscle tone, breathing problems, hearing and vision loss, problems with movement and balance, skin rashes, hair loss, and fungal infection. Treatment is supplemental biotin beginning at birth, which is why most newborns are screened for the condition, per the NIH.
Signs of less significant, partial biotin deficiency include skin rashes, hair loss, and weak muscle tone.
Other populations prone to biotin deficiency are pregnant people and people who drink alcohol heavily, because alcohol inhibits the absorption of biotin, the NIH says.
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