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Chronic pain is startlingly common—according to a 2023 study from the National Institutes of Health (NIH), 21% of American adults live with it—and yet, it remains notoriously difficult to treat. So it’s particularly welcome news that scientists have found that some who struggle with chronic pain may find relief with melatonin, a popular, safe, and affordable supplement marketed as a sleep aid.

The study, published in Pain , was a systematic review and meta-analysis of 23 randomized controlled trials, which enrolled a total of over 2,000 participants with either chronic or post-surgical musculoskeletal pain. Researchers compared…

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